Gut microbes can contribute to AD pathology and may help identifying novel markers and therapies against AD. Alzheimer's disease (AD) prevalence is increasing, but its etiology remains elusive. Conversely, AHAD increases acetate and propionate while reducing butyrate. By continuing you agree to the use of cookies. Herein, we examine how the gut microbiome differs in older adults with mild cognitive impairment compared to cognitively normal counterparts, and whether and how a modified Mediterranean-ketogenic diet (MMKD) alters the gut microbiome signature in association with cerebrospinal fluid (CSF) AD biomarkers. We use cookies to help provide and enhance our service and tailor content and ads. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment. Proteobacteria correlate positively with Aβ-42: Aβ-40 while fecal propionate and butyrate correlates negatively with Aβ-42 in subjects with mild cognitive impairment. A randomized, double-blind, cross-over, single-center pilot study of MMKD versus American Heart Association Diet (AHAD) intervention is performed on 17 subjects (age: 64.6 ± 6.4 yr), of which 11 have mild cognitive impairment, while 6 are cognitively normal. Generally speaking, it lowers glucose levels and hemoglobin A1c in people with diabetes, regardless of overweight or obesity. Notably, the abundance of Enterobacteriaceae, Akkermansia, Slackia, Christensenellaceae and Erysipelotriaceae increases while that of Bifidobacterium and Lachnobacterium reduces on MMKD, while AHAD increases Mollicutes. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment. while also evaluating the impact of a modified Mediterranean-ketogenic diet (MMKD) on gut microbiome composition, short-chain fatty acids (SCFAs) levels, and AD biomarkers. Author links open overlay panel Ravinder Nagpal a b Bryan J. Neth c d Shaohua Wang a b Suzanne Craft c Hariom Yadav a b. In someone previously under good control, it may allow reduction in drug dosages. The study identifies specific gut microbiome signatures that are associated with MCI and how … Gut microbiome, fecal short-chain fatty acids (SCFAs), and markers of AD in CSF including amyloid β (Aβ)-40 and Aß-42, total tau, and phosphorylated tau-181 (tau-p181) are measured at before and after diet interventions. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Subjects undergo MMKD and AHAD intervention for 6-weeks separated by 6-weeks washout periods. Several bacteria are differently affected by the two diets with distinct patterns between cognitively normal and impaired subjects. Published by Elsevier B.V. https://doi.org/10.1016/j.ebiom.2019.08.032. At baseline, subjects with normal vs. impaired cognition show no notable difference in microbiome diversity but several unique microbial signatures are detected in subjects with mild cognitive impairment. © 2019 The Authors. Copyright © 2020 Elsevier B.V. or its licensors or contributors. MMKD slightly reduces fecal lactate and acetate while increasing propionate and butyrate. The Ketogenic Mediterranean Diet is more of a glucose-control diet than a weight-loss diet. The data suggest that specific gut microbial signatures may depict the mild cognitive impairment and that the MMKD can modulate the gut microbiome and metabolites in association with improved AD biomarkers in CSF.